I *may* be ok with a JVR for Hamilton trade, I don't think they would do it - straight up.
Nylander, Marner and Matthews are basically untouchable, IMO.
I can't see a deal like that happening during the regular season. Trading a top 6 guy for immediate help on the blueline seems more like an off-season/draft type trade to make. Most teams that would want a JVR would be teams in a playoff position that want to add more scoring. Those types of teams aren't going to give up a top 4 D-man since they'll need him for the playoffs.
I could see a team that had high expectations of a Cup run but fizzled out in the playoffs in the first round wanting to shake up the team and adding a JVR in the summer. In that scenario I could see a high d-man come back.
If JVR was to be traded this season to a contender, I would expect the return to be a young up and coming defensive prospect and a pick. Not someone already established.